Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State

International audienceQuinoline-based oligoamide foldamers have been identified as a potent class of G-quadruplex DNA ligands. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report the cocrystal structure of anti-parallel hairpin dimeric DNA G-quadruplex (G4T4G4)2 with a helically folded tetra-quinolinecarboxamide bearing cationic side chain consistent with this hypothesis. Multivalent foldamer-DNA interactions are observed that modify the packing of (G4T4G4)2 in the solid state