Analisis Faktor Risiko Reproduksi Yang Berhubungan Dengan Kejadian Kanker Payudara Pada Wanita

Breast cancer is most commonly found in women, and is the second leading cause of death after cervical cancer. Due to its multifactorial nature, the cause of breast cancer is indeterminate. Epidemiological evidence suggests that there are 3 possible factors contributing to the occurrence of breast cancer, namely hormonal, genetic and environmental factors. North Sumatra is the 5th province having the highest breast cancer prevalence among all other provinces in Indonesia. The purpose of this study was to analyze various reproductive risk factors contributing to breast cancer incidence in women. The study was a retrospective case-control. Subjects were women with breast cancer who received care and treatment in H.Adam Malik General Hospital and dr.Pirngadi Medan General Hospital. The sample size was N=100 (n=50 – case group; n=50 – control group). The data were analyzed using bivariate analyses (Chi-square tests) and multivariate analyses (multiple logistic regressions). Bivariate analyses showed that reproductive risk factors associated with breast cancer were menarche period (p=0.001), parity (p=0.001), age of first pregnancy (p=0.001) and breastfeeding (p=0.002). Moreover, multivariate analyses showed statistically significant correlations (p <0.05) between the four reproductive risk factors and breast cancer incidence, including menarche period (OR=4.41, 95% CI: 1.33 ̶ 14.63), parity (OR=6.38, 95% CI : 1.57 ̶ 25.90), age of first pregnancy (OR=7.91, 95% CI: 1.86 to 33.60) and breastfeeding (OR= 4.24, 95% CI: 1.22 ̶ 14.76). In conclusion, the reproductive risks associated with breast cancer incidence in women were the menarche period of