Amyloidosis are metabolic conformational diseases caused by misfolding and aggregation of soluble proteins in insoluble fibrils which deposit squeezing out the functioning cells or block cell-to-cell connectivity. Amylin or Islet Amyloid Polypeptide (IAPP) is a 37 residue peptide hormone secreted by pancreatic β-cells together with insulin. Amylin forms deposits in pancreas and is a non-insulin-dependent type II diabetes disease agent. Six stranded single ß-sheets of amylin 10-29 residues QRLANFLVHSSNNFGAILSS (Amylin 10-29), was investigated by molecular dynamics (MD) simulations in a periodic box using Amber 9.0, f99 force field and isothermal-isobaric ensemble, NTP protocol (constant temperature, pressure and the number of particles). The...
Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein w...
<div><p>IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsicall...
A 37-residue of human islet amyloid polypeptide (hIAPP or amylin) is a main component of amyloid pla...
Most proteins do not aggregate while in their native functional states. However, they may be disturb...
The structural characterization of amyloid fibers is one of the most investigated areas in structura...
Most proteins do not aggregate while in their native functional states. However, they may be disturb...
Amyloid oligomers are considered to play essential roles in the pathogenesis of amyloid-related dege...
Amyloid oligomers are considered to play essential roles in the pathogenesis of amyloid-related dege...
Amyloid deposits of human islet amyloid polypeptide (hIAPP, or amylin) are almost always present in ...
Amiloidosis is the misfolding of soluble proteins followed by their self-assembling, resulting in ag...
Human islet amyloid polypeptide (hIAPP), a 37-residue protein cosecreted with insulin by β-cells in ...
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37-amino-acid peptide, co-secret...
The formation of amyloid fibrils is associated with major human diseases. Nevertheless, the molecula...
The formation of amyloid fibrils is associated with major human diseases. Nevertheless, the molecul...
Islet amyloid polypeptide, also known as amylin, forms aggregates that reduce the amount of insulin-...
Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein w...
<div><p>IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsicall...
A 37-residue of human islet amyloid polypeptide (hIAPP or amylin) is a main component of amyloid pla...
Most proteins do not aggregate while in their native functional states. However, they may be disturb...
The structural characterization of amyloid fibers is one of the most investigated areas in structura...
Most proteins do not aggregate while in their native functional states. However, they may be disturb...
Amyloid oligomers are considered to play essential roles in the pathogenesis of amyloid-related dege...
Amyloid oligomers are considered to play essential roles in the pathogenesis of amyloid-related dege...
Amyloid deposits of human islet amyloid polypeptide (hIAPP, or amylin) are almost always present in ...
Amiloidosis is the misfolding of soluble proteins followed by their self-assembling, resulting in ag...
Human islet amyloid polypeptide (hIAPP), a 37-residue protein cosecreted with insulin by β-cells in ...
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37-amino-acid peptide, co-secret...
The formation of amyloid fibrils is associated with major human diseases. Nevertheless, the molecula...
The formation of amyloid fibrils is associated with major human diseases. Nevertheless, the molecul...
Islet amyloid polypeptide, also known as amylin, forms aggregates that reduce the amount of insulin-...
Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein w...
<div><p>IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is an intrinsicall...
A 37-residue of human islet amyloid polypeptide (hIAPP or amylin) is a main component of amyloid pla...