In the brain the relations between free neurons and the conditioned ones establish the constraints for the informational neural processes. These constraints reflect the systemenvironment state, i.e. the dynamics of homeocognitive activities. The constraints allow us to define the cost function in the phase space of free neurons so as to trace the trajectories of the possible configurations at minimal cost while respecting the constraints imposed. Since the space of the free states is a manifold or a non orthogonal space, the minimum distance is not a straight line but a geodesic. The minimum condition is expressed by a set of ordinary differential equation ( ODE ) that in general are not linear. In the brain there is not...