For over thirty years I have argued that all branches of science and scholarship would have both their intellectual and humanitarian value enhanced if pursued in accordance with the edicts of wisdom-inquiry rather than knowledge-inquiry. I argue that this is true of mathematics. Viewed from the perspective of knowledge-inquiry, mathematics confronts us with two fundamental problems. (1) How can mathematics be held to be a branch of knowledge, in view of the difficulties that view engenders? What could mathematics be knowledge about? (2) How do we distinguish significant from insignificant mathematics? This is a fundamental philosophical problem concerning the nature of mathematics. But it is also a practical problem concerning mathem...