Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease.
- Labuschagne, Izelle
- Jones, Rebecca
- Callaghan, Jenny
- Whitehead, Daisy
- Dumas, Eve M
- Say, Miranda J
- Hart, Ellen P
- Justo, Damian
- Coleman, Allison
- Dar Santos, Rachelle C
- Frost, Chris
- Craufurd, David
- Tabrizi, Sarah J
- Stout, Julie C
- TRACK-HD Investigators
DOIAbstract
Facial emotion recognition impairments have been reported in Huntington's disease (HD). However, the nature of the impairments across the spectrum of HD remains unclear. We report on emotion recognition data from 344 participants comprising premanifest HD (PreHD) and early HD patients, and controls. In a test of recognition of facial emotions, we examined responses to six basic emotional expressions and neutral expressions. In addition, and within the early HD sample, we tested for differences on emotion recognition performance between those 'on' vs. 'off' neuroleptic or selective serotonin reuptake inhibitor (SSRI) medications. The PreHD groups showed significant (p<0.05) impaired recognition, compared to controls, on fearful, angry and su...
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