Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
- Schormair, B
- Zhao, C
- Bell, S
- Tilch, E
- Salminen, AV
- Putz, B
- Dauvilliers, Y
- Stefani, A
- Hogl, B
- Poewe, W
- Kemlink, D
- Sonka, K
- Bachmann, CG
- Paulus, W
- Trenkwalder, C
- Oertel, WH
- Hornyak, M
- Teder-Laving, M
- Metspalu, A
- Hadjigeorgiou, GM
- Polo, O
- Fietze, I
- Ross, OA
- Wszolek, Z
- Butterworth, AS
- Soranzo, N
- Ouwehand, WH
- Roberts, DJ
- Danesh, J
- Allen, RP
- Earley, CJ
- Ondo, WG
- Xiong, L
- Montplaisir, J
- Gan-Or, Z
- Perola, M
- Vodicka, P
- Dina, C
- Franke, A
- Tittmann, L
- Stewart, AFR
- Shah, SH
- Gieger, C
- Peters, A
- Rouleau, GA
- Berger, K
- Oexle, K
- Di Angelantonio, E
- Hinds, DA
- Muller-Myhsok, B
- Winkelmann, J
- Balkau, B
- Ducimetiere, P
- Eschwege, E
- Ranciere, F
- Alhenc-Gelas, F
- Gallois, Y
- Girault, A
- Fumeron, F
- Marre, M
- Roussel, R
- Bonnet, F
- Bonnefond, A
- Cauchi, S
- Froguel, P
- Cogneau, J
- Born, C
- Caces, E
- Cailleau, M
- Lantieri, O
- Moreau, JG
- Rakotozafy, F
- Tichet, J
- Vol, S
- Agee, M
- Alipanahi, B
- Auton, A
- Bell, RK
- Bryc, K
- Elson, SL
- Fontanillas, P
- Furlotte, NA
- Hinds, DA
- Hromatka, BS
- Huber, KE
- Kleinman, A
- Litterman, NK
- McIntyre, MH
- Mountain, JL
- Northover, CA
- Pitts, SJ
- Sathirapongsasuti, JF
- Sazonova, OV
- Shelton, JF
- Shringarpure, S
- Tian, C
- Tung, JY
- Vacic, V
- Wilson, CH
DOIAbstract
Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. Methods In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15 126 cases and 95 725 controls of European ancestry. We identified common variants by fixed-effect inverse-variance meta-analysis. Significant genome-wide signals (p≤5 × 10−8) were tested...
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