Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department
- Irwin, AD
- Grant, A
- Williams, R
- Kolamunnage-Dona, R
- Drew, RJ
- Paulus, S
- Jeffers, G
- Williams, K
- Breen, R
- Preston, J
- Appelbe, D
- Chesters, C
- Newland, P
- Marzouk, O
- McNamara, PS
- Diggle, PJ
- Carrol, ED
DOIAbstract
Improving the diagnosis of serious bacterial infections (SBIs) in the children's emergency department is a clinical priority. Early recognition reduces morbidity and mortality, and supporting clinicians in ruling out SBIs may limit unnecessary admissions and antibiotic use.A prospective, diagnostic accuracy study of clinical and biomarker variables in the diagnosis of SBIs (pneumonia or other SBI) in febrile children <16 years old. A diagnostic model was derived by using multinomial logistic regression and internally validated. External validation of a published model was undertaken, followed by model updating and extension by the inclusion of procalcitonin and resistin.There were 1101 children studied, of whom 264 had an SBI. A diagnostic ...
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