Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease.
- Khor, Chiea Chuen
- Davila, Sonia
- Shimizu, Chisato
- Sheng, Stephanie
- Matsubara, Tomoyo
- Suzuki, Yasuo
- Newburger, Jane W
- Baker, Annette
- Burgner, David
- Breunis, Willemijn
- Kuijpers, Taco
- Wright, Victoria J
- Levin, Michael
- Hibberd, Martin L
- Burns, Jane C
- US and International Kawasaki Disease Genetics Consortia
DOIAbstract
BACKGROUND: Kawasaki disease (KD) is a self limited vasculitis in which host genetics plays a prominent role. To further the understanding of the role of host genetics in KD, a three-stage genetic study was conducted that began with a family linkage study and ultimately involved more than 3000 individuals to identify new genetic contributions to KD susceptibility. METHODS AND RESULTS: A 26-family linkage study followed by fine mapping was performed in a cohort of 1284 KD subjects and their family members (total 3248 individuals). Suggestive evidence of disease linkage (logarithm of odds (LOD) ≥3.0, p<1.00×10(-4)) was found for five genomic locations (Chr 3q, 4q, 10p, 13q, 21q). Two of these loci (Chr 4q and Chr 13q) overlapped with validate...
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