Hearing loss in children treated for multidrug-resistant tuberculosis.
- Seddon, James A
- Thee, Stephanie
- Jacobs, Kayleen
- Ebrahim, Adam
- Hesseling, Anneke C
- Schaaf, H Simon
DOIAbstract
OBJECTIVE: The aminoglycosides and polypeptides are vital drugs for the management of multidrug-resistant (MDR) tuberculosis (TB). Both classes of drug cause hearing loss. We aimed to determine the extent of hearing loss in children treated for MDR-TB. METHODS: In this retrospective study, children (<15 years) admitted to Brooklyn Chest Hospital, Cape Town, South Africa, from January 2009 until December 2010, were included if treated for MDR-TB with injectable drugs. Hearing was assessed and classified using audiometry and otoacoustic emissions. RESULTS: Ninety-four children were included (median age: 43 months). Of 93 tested, 28 (30%) were HIV-infected. Twenty-three (24%) children had hearing loss. Culture-confirmed, as opposed to presumed...
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