Pattern-mixture models with proper time dependence

Recently, pattern-mixture modelling has become a popular tool for modelling incomplete longitudinal data. Such models are under-identified in the sense that, for any dropout pattern; the data provide no direct information on the-distribution of the unobserved outcomes, given the observed ones. One simple way of overcoming this problem, ordinary extrapolation of sufficiently simple pattern-specific-models, often produces rather unlikely descriptions; several authors consider identifying restrictions instead. Molenberghs et al. (1998) have constructed identifying restrictions corresponding to missing at random. In this paper, the family of restrictions where drop-out-does not depend on future, unobserved observations is identified. The ideas are illustrated using a clinical study of Alzheimer patients