This study examines the relationship between malaria treatment failure after sulfadoxine-pyrimethamine (S-P) chemotherapy and presence of mutations in the Plasmodium falciparum dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) genes (associated with resistance in vitro to S and P) before treatment. In Kenya, 38 malaria patients in a holoendemic area, and 21 in an epidemic area, participated in the trial in 1997-98. In the 2 areas, drug failure occurred in 76% and 75% of cases where any mutation in dhfr was seen (positive predictive values 76% and 75%: P = 0.003 and 0.008) and an identical association was seen with dhfr Asn-108. In the holoendemic area all occurrences of > or = 2 mutations in dhfr predicted drug failure. Onl...
Background: Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncompli...
Sulfadoxine-pyrimethamine (SP), the current first line antimalarial drug in Tanzania, is compromised...
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate ...
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as ...
To determine the relationship between mutations in dhfr and dhps and SP treatment failure in Plasmod...
Antimalarial resistance to sulfadoxine-pyrimethamine (SP) is mediated by mutations in the dihydrofol...
During an epidemic of Plasmodium falciparum malaria in Chogoria, Kenya, P. falciparum DNA was collec...
BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrof...
Background: Antifolate antimalarials like sulfadoxine-pyrimethamine are used as second-line treatme...
Tanzania Health Research BulletinSulfadoxine-pyrimethamine (SP), the current first line antimalarial...
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of un...
Purpose: Drug resistance is probably the greatest challenge to most malaria-control programmes. The ...
Background: In Tanzania, drug-resistant malaria parasites are an increasing public health concern. B...
Abstract. The efficacy of sulfadoxine/pyrimethamine (S/P) in treatment of uncomplicated falciparum m...
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as ...
Background: Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncompli...
Sulfadoxine-pyrimethamine (SP), the current first line antimalarial drug in Tanzania, is compromised...
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate ...
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as ...
To determine the relationship between mutations in dhfr and dhps and SP treatment failure in Plasmod...
Antimalarial resistance to sulfadoxine-pyrimethamine (SP) is mediated by mutations in the dihydrofol...
During an epidemic of Plasmodium falciparum malaria in Chogoria, Kenya, P. falciparum DNA was collec...
BACKGROUND: Drug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrof...
Background: Antifolate antimalarials like sulfadoxine-pyrimethamine are used as second-line treatme...
Tanzania Health Research BulletinSulfadoxine-pyrimethamine (SP), the current first line antimalarial...
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of un...
Purpose: Drug resistance is probably the greatest challenge to most malaria-control programmes. The ...
Background: In Tanzania, drug-resistant malaria parasites are an increasing public health concern. B...
Abstract. The efficacy of sulfadoxine/pyrimethamine (S/P) in treatment of uncomplicated falciparum m...
Mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium falciparum have been proposed as ...
Background: Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncompli...
Sulfadoxine-pyrimethamine (SP), the current first line antimalarial drug in Tanzania, is compromised...
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate ...