Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.

Gokhale, Nikhil H
Shirisha, K
Padhye, Subhash B
Croft, Simon L
Kendrick, Howard D
Mckee, Vickie

Publication date

January 2006

DOI

10.1016/j.bmcl.2005.09.061

Publisher

Elsevier BV

ISSN

0960-894X

Citation count (estimate)

Abstract

The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target

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Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.

Abstract

Extracted data

Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone.

Abstract

Extracted data

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