Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study.

Nitsch, Dorothea
Felber Dietrich, Denise
von Eckardstein, Arnold
Gaspoz, Jean-Michel
Downs, Sara H
Leuenberger, Philippe
Tschopp, Jean-Marie
Brändli, Otto
Keller, Roland
Gerbase, Margaret W
Probst-Hensch, Nicole M
Stutz, Elisabeth Zemp
Ackermann-Liebrich, Ursula
SAPALDIA team

Publication date

January 2006

DOI

10.1093/ndt/gfk021

Publisher

Oxford University Press (OUP)

ISSN

1460-2385

Citation count (estimate)

Abstract

BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its relationship to cardiovascular risk factors in the Swiss general population. METHODS: SAPALDIA comprises a random sample of the Swiss population established in 1991, originally to investigate the health effects of long-term exposure to air pollution. Participants were reassessed in 2002/3 and blood measurements were obtained (n = 6317). Renal function was estimated using the Cockcroft-Gault equation and the modified MDRD (four-component) equation incorporating age, race, gender and serum creatinine level. RESULTS: The estimated prevalence of im...