Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones.
- Papanastasiou, Ioannis
- Tsotinis, Andrew
- Zoidis, Grigoris
- Kolocouris, Nicolas
- Prathalingam, S Radhika
- Kelly, John M
Publication date
January 2009
DOI Publisher
Wiley ISSN
1860-7179 Citation count (estimate)
6Abstract
Treating African trypanosomiasis: The synthesis and biological evaluation of novel 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones, their 1-dioxa congeners and two 1-benzyladamantano 2-guanylhydrazones is reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered
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