Although the 38-kDa glycolipoprotein of Mycobacterium tuberculosis H37Rv is known to evoke prominent cellular and humoral immune responses in human tuberculosis (TB), little information is known about intracellular regulatory mechanisms involved in 38-kDa antigen (Ag)-induced host responses. In this study, we found that purified 38-kDa glycolipoprotein activates mitogen-activated protein kinases (MAPKs; extracellular signal-regulated kinase 1/2 [ERK1/2] and p38) and induces tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in human monocytes. When the 38-kDa Ag was applied to monocytes from TB patients and healthy controls, the activation of ERK1/2 and p38 MAPK and the subsequent cytokine secretion were greater in the monocyt...
The clinical course of mycobacterial infections is linked to the capacity of pathogenic strains to m...
Abstract Background Mycobacterium tuberculosis (Mtb) causes death of 2–3 million people every year. ...
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, infects one-third of the ...
The role of mitogen-activated protein kinase (MAPK) pathways in the secretion of tumor necrosis fact...
Group I CD1 proteins are specialized antigen-presenting molecules that present both microbial and se...
Here we investigated the role of the phosphatidylinositol 3-kinase (PI 3-K) and mitogen-activated pr...
BACKGROUND: The 30-kDa antigen (Ag) of Mycobacterium tuberculosis (M. tuberculosis) is a strong indu...
Changes in the levels of antiapoptotic protein B-cell lymphoma 2 (Bcl-2) protein has been reported i...
Knowledge of the molecular events regulating the innate response to Mycobacterium tuberculosis (Mtb)...
Setting: The success of Mycobacterium tuberculosis as a human pathogen depends on its ability to tol...
We previously demonstrated that Mycobacterium tuberculosis (M. tbc)-induced interleukin (IL)-12 expr...
This study characterized the upstream signalling molecules involved in extracellular signal-regulate...
Signalling cascades involved in chemokine production by human phagocytes following infection with My...
Following infection of the host by Mycobacterium tuberculosis, induction of cytokines is a major def...
Different strains of Mycobacterium tuberculosis (M. tuberculosis) are known to modify the host immun...
The clinical course of mycobacterial infections is linked to the capacity of pathogenic strains to m...
Abstract Background Mycobacterium tuberculosis (Mtb) causes death of 2–3 million people every year. ...
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, infects one-third of the ...
The role of mitogen-activated protein kinase (MAPK) pathways in the secretion of tumor necrosis fact...
Group I CD1 proteins are specialized antigen-presenting molecules that present both microbial and se...
Here we investigated the role of the phosphatidylinositol 3-kinase (PI 3-K) and mitogen-activated pr...
BACKGROUND: The 30-kDa antigen (Ag) of Mycobacterium tuberculosis (M. tuberculosis) is a strong indu...
Changes in the levels of antiapoptotic protein B-cell lymphoma 2 (Bcl-2) protein has been reported i...
Knowledge of the molecular events regulating the innate response to Mycobacterium tuberculosis (Mtb)...
Setting: The success of Mycobacterium tuberculosis as a human pathogen depends on its ability to tol...
We previously demonstrated that Mycobacterium tuberculosis (M. tbc)-induced interleukin (IL)-12 expr...
This study characterized the upstream signalling molecules involved in extracellular signal-regulate...
Signalling cascades involved in chemokine production by human phagocytes following infection with My...
Following infection of the host by Mycobacterium tuberculosis, induction of cytokines is a major def...
Different strains of Mycobacterium tuberculosis (M. tuberculosis) are known to modify the host immun...
The clinical course of mycobacterial infections is linked to the capacity of pathogenic strains to m...
Abstract Background Mycobacterium tuberculosis (Mtb) causes death of 2–3 million people every year. ...
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, infects one-third of the ...