Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
- Talmud, Philippa J
- Drenos, Fotios
- Shah, Sonia
- Shah, Tina
- Palmen, Jutta
- Verzilli, Claudio
- Gaunt, Tom R
- Pallas, Jacky
- Lovering, Ruth
- Li, Kawah
- Casas, Juan Pablo
- Sofat, Reecha
- Kumari, Meena
- Rodriguez, Santiago
- Johnson, Toby
- Newhouse, Stephen J
- Dominiczak, Anna
- Samani, Nilesh J
- Caulfield, Mark
- Sever, Peter
- Stanton, Alice
- Shields, Denis C
- Padmanabhan, Sandosh
- Melander, Olle
- Hastie, Claire
- Delles, Christian
- Ebrahim, Shah
- Marmot, Michael G
- Smith, George Davey
- Lawlor, Debbie A
- Munroe, Patricia B
- Day, Ian N
- Kivimaki, Mika
- Whittaker, John
- Humphries, Steve E
- Hingorani, Aroon D
- ASCOT investigators
- NORDIL investigators
- BRIGHT Consortium
DOIAbstract
Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n=5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16 genes/regions associated with 3 major lipid fractions and 2 apolipoprotein components at p12,500) revealed previously unreported associations of SH2B3 (p1 mmol/L in LDL cholesterol [approximately 1 SD of the trait distribution]). These data suggest that multiple common alleles of small effect can make important contributions to individual differences in blood lipids potentially relevant to the assessment of CVD risk. These genes provide further insights into lipid metabolism and the likely effects o...
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