Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania.

Crump, John A
Ramadhani, Habib O
Morrissey, Anne B
Msuya, Levina J
Yang, Lan-Yan
Chow, Shein-Chung
Morpeth, Susan C
Reyburn, Hugh
Njau, Boniface N
Shaw, Andrea V
Diefenthal, Helmut C
Bartlett, John A
Shao, John F
Schimana, Werner
Cunningham, Coleen K
Kinabo, Grace D

Publication date

January 2011

DOI

10.1111/j.1365-3156.2011.02774.x

Publisher

Wiley

ISSN

1360-2276

Citation count (estimate)

Abstract

OBJECTIVE: To describe the contribution of paediatric HIV and of HIV co-infections to admissions to a hospital in Moshi, Tanzania, using contemporary laboratory methods. METHODS: During 1 year, we enrolled consecutively admitted patients aged ≥2 months and <13 years with current or recent fever. All patients underwent standardized clinical history taking, a physical examination and HIV antibody testing; standard aerobic blood cultures and malaria film were also done, and hospital outcome was recorded. Early infant HIV diagnosis by HIV-1 RNA PCR was performed on those aged <18 months. HIV-infected patients also received serum cryptococcal antigen testing and had their CD4-positive T-lymphocyte count and percent determined. RESULTS: A total o...