Early enteral tube feeding in optimizing treatment of hyperemesis gravidarum: the Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER) randomized controlled trial
- Grooten, I.J.
- Koot, M.H.
- Post, J.A. van der
- Bais, J.M.
- Ris-Stalpers, C.
- Naaktgeboren, C.
- Bremer, H.A.
- Ham, D.P. van der
- Heidema, W.M.
- Huisjes, A.
- Kleiverda, G.
- Kuppens, S.
- Laar, J.O.E.H. van
- Langenveld, J.
- Made, F. van der
- Pampus, M.G. van
- Papatsonis, D.
- Pelinck, M.J.
- Pernet, P.J.
- Rheenen, L. van
- Rijnders, R.J.
- Scheepers, H.C.
- Vogelvang, T.E.
- Mol, B.W.
- Roseboom, T.J.
- Painter, R.C.
DOIAbstract
Item does not contain fulltextBackground: Hyperemesis gravidarum (HG) leads to dehydration, poor nutritional intake, and weight loss. HG has been associated with adverse pregnancy outcomes such as low birth weight. Information about the potential effectiveness of treatments for HG is limited.Objective: We hypothesized that in women with HG, early enteral tube feeding in addition to standard care improves birth weight.Design: We performed a multicenter, open-label randomized controlled trial [Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER)] in 19 hospitals in the Netherlands. A total of 116 women hospitalized for HG between 5 and 20 wk of gestation were randomly allocated to enteral tube feeding for >/=7 ...
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