CHROMOSOMAL rearrangements are the major cause of inherited human disease and fetal loss 1 . Translations 2 and loss of heterozygosity 3 are important genetic changes causally involved in neoplasia. Chromosomal variants, such as deficiencies, are commonly exploited in genetic screens in organisms such as Drosophila because a small portion of the genome is functionally hemizygous 4 . In the mouse, deficiencies are not generally available, thus genetic screens for recessive mutations are cumbersome 5 . We report here that defined deficiencies, inversions and duplications extending to 3-4 cM can be constructed in embryonic stem cells. This was achieved by consecutive targeting of loxP recombination substrates to the end points of a genetic i...
<div><p>Deletions, duplications, or inversions can be produced depending on the relative orientation...
Deletions, duplications, and inversions of large genomic regions covering several genes are an impor...
Feasibility of chromosomal manipulation in mammalian cells was first reported 15 years ago. Although...
Chromosomal rearrangements have been instrumental in genetic studies in Drosophila. Visibly marked d...
Experimental approaches for deciphering the function of human genes rely heavily on our ability to g...
Gene targeting in mouse embryonic stem (ES) cells can be used to generate single gene mutations or d...
Functional studies of large transcription units, clustered genes and chromosomal loci require the de...
Chromosome engineering in mice enables the construction of models of human chromosomal diseases and ...
Chromosome rearrangements cause genomic disorders and cancer in human. Region-specific low-copy repe...
International audienceLoss or gain of whole chromosomes, or parts of chromosomes, is found in variou...
International audienceLoss or gain of whole chromosomes, or parts of chromosomes, is found in variou...
textabstractChromosome rearrangements, such as large deletions, inversions, or translocations, media...
This article has been adapted, with permission, from a paper originally published in Médecine/ Scien...
Mouse models of human cancers are important for understanding determinants of overt disease and for ...
SummaryAll somatic mammalian cells carry two copies of chromosomes (diploidy), whereas organisms wit...
<div><p>Deletions, duplications, or inversions can be produced depending on the relative orientation...
Deletions, duplications, and inversions of large genomic regions covering several genes are an impor...
Feasibility of chromosomal manipulation in mammalian cells was first reported 15 years ago. Although...
Chromosomal rearrangements have been instrumental in genetic studies in Drosophila. Visibly marked d...
Experimental approaches for deciphering the function of human genes rely heavily on our ability to g...
Gene targeting in mouse embryonic stem (ES) cells can be used to generate single gene mutations or d...
Functional studies of large transcription units, clustered genes and chromosomal loci require the de...
Chromosome engineering in mice enables the construction of models of human chromosomal diseases and ...
Chromosome rearrangements cause genomic disorders and cancer in human. Region-specific low-copy repe...
International audienceLoss or gain of whole chromosomes, or parts of chromosomes, is found in variou...
International audienceLoss or gain of whole chromosomes, or parts of chromosomes, is found in variou...
textabstractChromosome rearrangements, such as large deletions, inversions, or translocations, media...
This article has been adapted, with permission, from a paper originally published in Médecine/ Scien...
Mouse models of human cancers are important for understanding determinants of overt disease and for ...
SummaryAll somatic mammalian cells carry two copies of chromosomes (diploidy), whereas organisms wit...
<div><p>Deletions, duplications, or inversions can be produced depending on the relative orientation...
Deletions, duplications, and inversions of large genomic regions covering several genes are an impor...
Feasibility of chromosomal manipulation in mammalian cells was first reported 15 years ago. Although...