Uncover elements of the GLUT4 pathway that are altered by insulin resistance

Type 2 diabetes is becoming a more apparent health problem in the world. This disease is marked by insulin resistance, which causes pathological states due to a too high blood glucose level. Therefore, research is trying to elucidate the details of the insulin resistance mechanism. The GLUT4 pathway is the main focus of this research because insulin, besides exercise, is an element that is able to activate the GLUT4 pathway via PI3K and APS, leading towards glucose uptake. Elucidating the elements of these pathways that are affected and altered by insulin resistance in comparison with normal functioning insulin plus the mechanism it does so, possibly could provide therapeutic interventions to treat or even cure insulin resistance, and so type 2 diabetes. This literature study shows the current knowledge of which elements of the GLUT4 pathway are affected by insulin resistance by going through the GLUT4 pathway. Also therapeutic interventions based on this elements will be discussed.