De regulatie van de activiteit van de zona glomerulosa bij de rat; een enzymhistochemisch onderzoek.

In this thesis an account is given of a number of experiments undertaken to investigate, histological and enzyme histochemical techniques, the reaction of the zona glomerulosa of the rat adrenal cortex when challenged acutely and chronically. Enzymes investigated were glucose-6-phosphate dehydrogenase, NADP-dependent isocitrate dehydrogenase, succinate dehydrogenase, NADPH-tetrazolium reductase, NADH-tetrazolium reductase and 3,i-hydroxysteroid dehydrogenase. The juxtaglomerular index of HARTROFT and HARTROFT (1953) was used to assess renin-angio tensin-system (RAS) activity. A short introduction, explaining the reason for undertaking this investigation, is followed a review of the literature in chapter 1. Chapter II deals with materials and methods used. In Chapter III a description of the experiments and their results is given.