A pool of synthetic oligonucleotides was used to identify the gene encoding tetanus toxin on a 75-kbp plasmid from a toxigenic non-sporulating strain of Clostridium tetani. The nucleotide sequence contained a single open reading frame coding for 1315 amino acids corresponding to a polypeptide with a mol. wt of 150700. In the mature toxin molecule, proline (2) and serine (458) formed the N termini of the 52288 mol. wt light chain and the 98300 mol. wt heavy chain, respectively. Cysteine (467) was involved in the disulfide linkage between the two subchains. The amino acid sequences of the tetanus toxin revealed striking homologies with the partial amino acid sequences of botulinum toxins A, B, and E, indicating that the neurotoxins from C. te...
To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their a...
Abstract: Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and ...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
A pool of synthetic oligonucleotides was used to identify the gene encoding tetanus toxin on a 75-kb...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
International audienceBotulinum and tetanus neurotoxins are structurally and functionally related 15...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
Clostridium tetani and Clostridium botulinum produce two of the most potent neurotoxins known, tetan...
International audienceClostridium tetani produces a potent neurotoxin, the tetanus toxin (TeNT), whi...
Background: Light chain (LC) and heavy chain carboxyterminal subdomain (HCC) fragments are the most ...
To define conserved domains within the light (L) chains of clostridial neurotoxins, we determined th...
Fragment C is the C-terminal domain of the heavy chain of tetanus toxin that can promote the immune ...
AbstractThe activity of the light (L) chain of tetanus toxin, and of mutants constructed by site-dir...
To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their a...
To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their a...
Abstract: Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and ...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
A pool of synthetic oligonucleotides was used to identify the gene encoding tetanus toxin on a 75-kb...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
International audienceBotulinum and tetanus neurotoxins are structurally and functionally related 15...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...
Clostridium tetani and Clostridium botulinum produce two of the most potent neurotoxins known, tetan...
International audienceClostridium tetani produces a potent neurotoxin, the tetanus toxin (TeNT), whi...
Background: Light chain (LC) and heavy chain carboxyterminal subdomain (HCC) fragments are the most ...
To define conserved domains within the light (L) chains of clostridial neurotoxins, we determined th...
Fragment C is the C-terminal domain of the heavy chain of tetanus toxin that can promote the immune ...
AbstractThe activity of the light (L) chain of tetanus toxin, and of mutants constructed by site-dir...
To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their a...
To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their a...
Abstract: Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and ...
The TetR gene immediately upstream from the tetanus toxin (TeTx) gene was characterized. It encodes ...