Interleukin-1b-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and a-melanocyte-stimulating hormone prevented these effects
- Machado, Ivana Noelia
- Gonzalez, Patricia Verónica
- Vilcaes, Aldo Alejandro
- Carniglia, Lila
- Schiöth, Helgi B.
- Lasaga, Mercedes Isabel
- Scimonelli, Teresa Nieves
DOIAbstract
The immune system is an important modulator of learning, memory and neural plasticity. Interleukin 1β (IL-1β), a pro-inflammatory cytokine, significantly affects several cognitive processes. Previous studies by our group have demonstrated that intrahippocampal administration of IL-1β impairs reconsolidation of contextual fear memory. This effect was reversed by the melanocortin alpha-melanocyte-stimulating hormone (α-MSH). The mechanisms underlying the effect of IL-1β on memory reconsolidation have not yet been established. Therefore, we examined the effect of IL-1β on glutamate release, ERK phosphorylation and the activation of the transcription factor zinc finger- 268 (zif268) during reconsolidation. Our results demonstrated that IL-1β in...
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