One pot ‘click’ reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition
- Campbell-Verduyn, Lachlan S.,
- Szymański, Wiktor,
- Postema, Christiaan P.,
- Dierckx, Rudi A.,
- Elsinga, Philip H.,
- Janssen, Dick B.,
- Feringa, Ben L.,
Publication date
January 2010
DOI ISSN
1359-7345 Language
English Citation count (estimate)
60Abstract
Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
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