Studies on antibiotic aerosols for inhalation in cystic fibrosis

In this thesis, studies on the treatment of CF patients with antibiotic containing aerosols are described. After an overview of the history of cystic fibrosis related to inhalation therapy in chapter 1, chapter 2 deals with the first European consensus on inhaled medication and inhalation devices in CF. This document describes the current knowledge on treatment with inhaled drugs (among which are antimicrobial agents). Next to the drugs currently in use and new drug therapies in development, the fundamentals of inhalation in CF treatment and practical aspects of inhalation of drugs (e.g. compatibility of mixtures and cleaning) are described. This comprehensive review incorporates the fact that several new drugs, drug formulations and new inhalation devices have been developed and have been marketed recently. The consensus is intended as a reference document which may form the basis for an improved understanding of inhalation treatment in CF by clinicians, pharmacists and other health care professionals and for further research activities. ... Zie: Samenvatting