Disposition and effects of some non-depolarizing neuromuscular blocking agents in animal and man

The two marjor properties to be considered are: - the degree of paralysis, which depends on the affinity of the relaxant tot the cholinergic receptor in the end-plate and hence on its local concentration. It is assumed that the latter is determined by the plasma concentration. - the duration of action, which is mainly determined by the course of the plasma concentration and therefore by the distribution, biotransformation and excretion pattern of the drug. We investigate: - the disposition and biotransformation of pancuronium and its analogues as well as the relationship between these metabolic processes and the paralyzing effects of these compounds in the cat. - the metabolic fate of pancuronium bromide and the value of the blood levels of pancuronium as an index of its neuromuscular blocking effects in anesthetized patients. - the metabolic fate of gallamine triethiodide in surgical patients under general anesthesia. ... Zie: Summary