Add to ORKGThis thesis deals with the optimalization of quantitative receptor assays (QRA) of anticholinergic drugs. QRA have recently emerged as a new tool in bioanalysis, offering challenging perspectives with regard to improving senstitivies and/or selectivities. Similar to immunoassays, QRA is a binding assay in which an anlyte and a (radio)labelled ligand compete for the binding to a spectific protein. ... Zie: Summary
Exploring new chemical entities in drug discovery requires extensive investigations on libraries of ...
The M₁ muscarinic acetylcholine receptor (mAChR) is predominantly expressed in the brain where it pl...
In order to optimize quantitative receptor assays for anticholinergics, the different receptor prepa...
This thesis deals with the development and the application of a radioreceptor assay in the bioanalys...
For the purpose of quantitative receptor assays, a three-step solubilization procedure including thr...
Receptor proteins play an essential role in life. All organisms, from bacteria to plants, animals an...
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Inorganic and Org...
This report examines the development of quantitative structure‐activity relationships (QSAR) in the ...
In this article, a single-label separation-free fluorescence technique is presented as a potential s...
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligan...
The presented purification procedure for the muscarinic receptor from calf striatum includes the ext...
Receptor assays occupy a particular position in the methods used in bioanalysis, as they do not expl...
The heuristic-direct QSAR (quantitative structure-activity relationships) approach has been applied ...
We measured the intrinsic relative activity (RAi) of muscarinic agonists to detect possible selectiv...
G protein coupled receptors (GPCRs) are the largest receptor family in mammalian genomes and are kno...
Exploring new chemical entities in drug discovery requires extensive investigations on libraries of ...
The M₁ muscarinic acetylcholine receptor (mAChR) is predominantly expressed in the brain where it pl...
In order to optimize quantitative receptor assays for anticholinergics, the different receptor prepa...
This thesis deals with the development and the application of a radioreceptor assay in the bioanalys...
For the purpose of quantitative receptor assays, a three-step solubilization procedure including thr...
Receptor proteins play an essential role in life. All organisms, from bacteria to plants, animals an...
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Inorganic and Org...
This report examines the development of quantitative structure‐activity relationships (QSAR) in the ...
In this article, a single-label separation-free fluorescence technique is presented as a potential s...
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligan...
The presented purification procedure for the muscarinic receptor from calf striatum includes the ext...
Receptor assays occupy a particular position in the methods used in bioanalysis, as they do not expl...
The heuristic-direct QSAR (quantitative structure-activity relationships) approach has been applied ...
We measured the intrinsic relative activity (RAi) of muscarinic agonists to detect possible selectiv...
G protein coupled receptors (GPCRs) are the largest receptor family in mammalian genomes and are kno...
Exploring new chemical entities in drug discovery requires extensive investigations on libraries of ...
The M₁ muscarinic acetylcholine receptor (mAChR) is predominantly expressed in the brain where it pl...
In order to optimize quantitative receptor assays for anticholinergics, the different receptor prepa...