Modulation of noradrenergic neurotransmission by prejunctional auto- and heteroreceptors in the freely moving rat.

Prejunctional receptors modulating noradrenaline release from sympathetic nerves have been studied extensively during the last two decades. Most evidence supporting a modulatory role for these receptors has been obtained from studies using isolated tissues, in situ perfused organs, pithed animals or anaesthetized animals. In this thesis two different models were used to study the in vivo function and capacity of prejunctional auto- and heteroreceptors modulating endogenous noradrenaline overflow in the vasculature of freely moving rats. ... Zie: Summary