The antiproteinuric effect of ace inhibition in renal disease

In 1985 some studies were published showing that angiotensin converting enzyme (ACE) inhibition not only reduced the elevated blood pressure in animals with chronic renal failure (experimentally induced by renal ablation or by induced diabetic nephropathy), but also prevented the development of glomerular damage with proteinuria and loss of renal function. This beneficial effect of ACE inhibition was attributed to the prevention of glomerular hypertension. At the same time it was reported that ACE inhibition could reduce proteinuria in patients with advanced diabetic nephropathy. ACE inhibitors might thus be an attractive alternative for NSAIDs as antiproteinuric treatment, possibly being renoprotective and being generally well tolerated. The efficacy of the proteinuria lowering effect of ACE inhibition, and the mechanism of this effect, are studied in this thesis. ... Zie: Summary