Approaches to drug resistance in solid tumors : with emphasis on lung cancer

De novo or acquired resistance of tumor cells to anticancer agents remains a major problem for the therapeutic efficacy of chemotherapeutic drugs. Most solid tumors are intrinsically insensitive or acquire resistance after initial response to chemotherapy. Different mechanisms seem to play a role in drug resistance such as the overexpression of membrane efflux pumps, a decrease in the activity of target enzymes, and an increase in cellular detoxifying and DNA repair capacity. ... Zie: Summary