Genetic contributions to the classification of renal cell cancer

he aim of any histopathological classification is to use morphological criteria to identify disease states which are biologically distinct, the recognition of which are of clinical value [31]. Dilferent classification systems are currently in use for renal cell cancer (RCC) but their criteria are not always conclusive. This is not surprising since renal cancers display a heterogeneous morphology and their phenotype may change dramatically during progression [27]. The considerable diversity of RCC stresses the need for a more extended and refined classification than the commonly used WHO classification, which divides renal tumors into adenomas, carcinomas, and others, and does not allow extensive subtyping [2]. ... Zie: Summary