In this study the syntheses of 11 novel lignans are described. Their cytotoxicities are studied in GLC4, a human small cell lung carcinoma cell line, using the microculture tetrazolium (MTT) assay. Ten of these compounds were substituted with a menthyloxy group on the 5-position of the lactone. These compounds can easily be prepared in (novel) ‘one-pot’, three- or four-step syntheses. In addition, methods for controlling the stereogenic centers are described. Furthermore, five naturally occurring podophyllotoxin-related compounds were tested. The cytotoxicities of all lignan compounds, and of three non-lignan intermediates originating from the syntheses, were compared with the clinically applied anticancer agents etoposide, teniposide, and ...
4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. Th...
Despite prevention and treatment options, breast cancer (BC) has become one of the most important is...
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae)...
In this study the syntheses of 11 novel lignans are described. Their cytotoxicities are studied in G...
In this study the syntheses of 11 novel lignans are described. Their cytotoxicities are studied in G...
The present study describes the preliminary evaluation of the cytotoxic activity of a podophyllotoxi...
Podophyllotoxin derivatives like etoposide, etophos , and teniposide are used clinically as potent ...
Podophyllotoxin is a lignan that occurs in several plant species. Its cytotoxic activity is well-kno...
Podophyllotoxin derivatives like etoposide 7a, etophos 7b, and teniposide 7c are used clinically as ...
Lignans comprise a family of secondary metabolites existing widely in plants and also in human food ...
The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-...
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were pr...
Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinol...
International audienceA concise and versatile synthetic strategy for the total synthesis of arylnaph...
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae)...
4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. Th...
Despite prevention and treatment options, breast cancer (BC) has become one of the most important is...
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae)...
In this study the syntheses of 11 novel lignans are described. Their cytotoxicities are studied in G...
In this study the syntheses of 11 novel lignans are described. Their cytotoxicities are studied in G...
The present study describes the preliminary evaluation of the cytotoxic activity of a podophyllotoxi...
Podophyllotoxin derivatives like etoposide, etophos , and teniposide are used clinically as potent ...
Podophyllotoxin is a lignan that occurs in several plant species. Its cytotoxic activity is well-kno...
Podophyllotoxin derivatives like etoposide 7a, etophos 7b, and teniposide 7c are used clinically as ...
Lignans comprise a family of secondary metabolites existing widely in plants and also in human food ...
The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-...
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were pr...
Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinol...
International audienceA concise and versatile synthetic strategy for the total synthesis of arylnaph...
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae)...
4-O-Podophyllotoxin sulfamate derivatives were prepared using the natural lignan podophyllotoxin. Th...
Despite prevention and treatment options, breast cancer (BC) has become one of the most important is...
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae)...