Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthma, with a maternal history being a more significant risk factor for progeny than paternal history. We hypothesized that recall Th1- or Th2-type immune responses during pregnancy would result in transfer of maternal factors that would differentially impact development of immune responsiveness in offspring. Following weaning, susceptibility and severity of allergic airway disease (a murine model of human asthma) was evaluated in progeny, disease being elicited by immunization with OVA-Al(OH)3 and challenge with aerosolized OVA. We found that progeny of mothers with Th1-biased immunity to OVA subjected to recall aerosol challenge during...
Background: Mice models suggest epigenetic inheritance induced by parental allergic disease activity...
IgE is an important trigger in allergy and asthma, diseases whose development is suggested to depend...
Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure t...
Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthm...
The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years ...
Background: Maternal asthma during pregnancy is considered an environmental risk factor for asthma d...
Recent population-based studies of expecting mothers identified a unique profile of immune markers t...
Background Maternal asthma during pregnancy is considered an environmental risk factor for asthma d...
Abstract Background Offspring of asthmatic mothers have increased risk of developing asthma, based o...
Antigen challenge in early life, even before birth has been shown to crucially influence an individu...
Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and pat...
Background Mice models suggest epigenetic inheritance induced by parental allergic disease activity....
Asthma is a complex heterogeneous disease influenced by many factors, such as genetic background and...
Allergic respiratory diseases such as bronchial asthma are believed to result directly from the repe...
The state of the mother's immune system during pregnancy has an important role in fetal development ...
Background: Mice models suggest epigenetic inheritance induced by parental allergic disease activity...
IgE is an important trigger in allergy and asthma, diseases whose development is suggested to depend...
Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure t...
Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthm...
The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years ...
Background: Maternal asthma during pregnancy is considered an environmental risk factor for asthma d...
Recent population-based studies of expecting mothers identified a unique profile of immune markers t...
Background Maternal asthma during pregnancy is considered an environmental risk factor for asthma d...
Abstract Background Offspring of asthmatic mothers have increased risk of developing asthma, based o...
Antigen challenge in early life, even before birth has been shown to crucially influence an individu...
Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and pat...
Background Mice models suggest epigenetic inheritance induced by parental allergic disease activity....
Asthma is a complex heterogeneous disease influenced by many factors, such as genetic background and...
Allergic respiratory diseases such as bronchial asthma are believed to result directly from the repe...
The state of the mother's immune system during pregnancy has an important role in fetal development ...
Background: Mice models suggest epigenetic inheritance induced by parental allergic disease activity...
IgE is an important trigger in allergy and asthma, diseases whose development is suggested to depend...
Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure t...