Recent studies, including two in this issue, report heterozygous missense mutations in the U2AF1 and SF3B1 genes that encode spliceosome subunits. U2AF1 is frequently mutated in myeloid hematopoietic malignancies, especially in myelodysplastic syndrome (MDS), and SF3B1 is frequently mutated in both MDS and chronic lymphocytic leukemia (CLL).Christopher N Hahn & Hamish S Scot
A cohort of MDS patients was examined for mutations affecting four splice genes (SF3B1, SRSF2, ZRSR2...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...
Precursor mRNA splicing is catalyzed by the spliceosome, a macromolecule composed of small nuclear R...
Somatic mutations of the spliceosomal machinery occur frequently in adult patients with myelodysplas...
Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid ma...
Chronic myelomonocytic leukemia is a heterogeneous disease with multifactorial molecular pathogenesi...
Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) ...
Myelodysplastic syndromes (MDS) are characterized by recurrent somatic alterations often affecting c...
Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove...
Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndrome...
Myelodysplastic syndromes (MDS) are the most common myeloid cell malignancy in adults in the US, cha...
SummaryHeterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼11% of patients with m...
Myelodysplastic syndromes (MDS) are the most common myeloid malignancies of the elderly, characteriz...
16 Pág. Departamento de Reproducción AnimalMutations in splicing factors are recurrent somatic alt...
A cohort of MDS patients was examined for mutations affecting four splice genes (SF3B1, SRSF2, ZRSR2...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...
Precursor mRNA splicing is catalyzed by the spliceosome, a macromolecule composed of small nuclear R...
Somatic mutations of the spliceosomal machinery occur frequently in adult patients with myelodysplas...
Splicing factor gene mutations are the most frequent mutations found in patients with the myeloid ma...
Chronic myelomonocytic leukemia is a heterogeneous disease with multifactorial molecular pathogenesi...
Myelodysplastic syndromes (MDS) and related myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) ...
Myelodysplastic syndromes (MDS) are characterized by recurrent somatic alterations often affecting c...
Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove...
Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndrome...
Myelodysplastic syndromes (MDS) are the most common myeloid cell malignancy in adults in the US, cha...
SummaryHeterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼11% of patients with m...
Myelodysplastic syndromes (MDS) are the most common myeloid malignancies of the elderly, characteriz...
16 Pág. Departamento de Reproducción AnimalMutations in splicing factors are recurrent somatic alt...
A cohort of MDS patients was examined for mutations affecting four splice genes (SF3B1, SRSF2, ZRSR2...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (...