Polyp recurrence after endoscopic mucosal resection of sessile and flat colonic adenomas

Background: Endoscopic mucosal resection (EMR) is used for treatment of sessile and flat colonic adenomas. There is limited data comparing polyp recurrence between piecemeal and en-bloc resections. Aim: The purpose of this study was to evaluate the incidence density and predictive factors for polyp recurrence after piecemeal and en-bloc resections. Methods: Patients undergoing EMR of flat or sessile adenomas C10 mm were included. Incidence density (ID) and incidence rate ratio (IRR) of polyp recurrence were calculated. Predictive factors for recurrence were assessed by multivariate analysis using logistic regression. Results: A total of 105 patients (males 54, mean age 68) with 121 polyps were included. Sixty-seven polyps (mean size ± SD, 23.3 ± 9.2 mm) were resected piecemeal and 54 polyps (mean size 14.7 ± 5.1 mm) were resected enbloc. There were 12 recurrences in the piecemeal group and two in the en-bloc group. The ID of polyp recurrence in the piecemeal group was 13.1 (95% CI 7.43–23.03) and in the en-bloc group was 2.7 (95% CI 0.67–10.78) per 100 person-years of follow-up. Piecemeal resections were 5.5 (95% CI 1.1–30.48, P = 0.045) times and flat polyps were 6.6 (95% CI 1.22–35.53, P = 0.028) times more likely to result in recurrence compared to en-bloc resections and sessile polyps, respectively. In the piecemeal group, additional use of argon plasma coagulation (APC) did not affect the recurrence (OR 0.46, P = 0.29). Conclusions: Piecemeal resections and flat polyps are associated with higher recurrence following EMR. Additional use of APC did not affect the recurrence rates after piecemeal resection.J. Mannath, V. Subramanian, R. Singh, E. Telakis and K. Ragunat