HTR2A gene variation is involved in antidepressant treatment response

Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.Susanne Lucae, Marcus Ising, Sonja Horstmann, Bernhard T. Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschk