Background: In recent years, the molecular underpinnings of the long-observed resemblance between neoplastic and immature tissue have begun to emerge. Genome-wide transcriptional profiling has revealed similar gene expression signatures in several tumor types and early developmental stages of their tissue of origin. However, it remains unclear whether such arelationship is a universal feature of malignancy, whether heterogeneities exist in the developmental component of different tumor types and to which degree the resemblance between cancer and development is a tissue-specific phenomenon. Results: We defined a developmental landscape by summarizing the main features of ten developmental time courses and projected gene expression from a var...
AbstractAs the process of tumor progression proceeds from the normal cellular state to a preneoplast...
Carcinogenesis is commonly referred to as a multi-step process in which normal cells develop progres...
Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germlin...
A systematic analysis of the relationship between the neoplastic and developmental transcriptome pro...
Large, multidimensional cancer datasets provide a resource that can be mined to identify candidate t...
The expression level of each gene in each sample was calculated relative to that in adult colon. Gen...
Development requires the careful orchestration of several biological events in order to create any s...
© 2018 Dr. Anna Sofia Trigos GomezAll biological systems follow the rules and constraints imposed du...
The majority of cancer evolution studies involve individual-based approaches that neglect the popula...
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis i...
<p>Over the past several decades, many genes have been discovered that govern important functions in...
This review paper is intended to bring together common features of two important new approaches to c...
Significant alterations in signaling pathways and transcriptional regulatory programs together repre...
Fate and identity of eukaryotic cells are results of the cooperative function of biological features...
Background The human genome contains a large amount of cis-regulatory DNA elements r...
AbstractAs the process of tumor progression proceeds from the normal cellular state to a preneoplast...
Carcinogenesis is commonly referred to as a multi-step process in which normal cells develop progres...
Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germlin...
A systematic analysis of the relationship between the neoplastic and developmental transcriptome pro...
Large, multidimensional cancer datasets provide a resource that can be mined to identify candidate t...
The expression level of each gene in each sample was calculated relative to that in adult colon. Gen...
Development requires the careful orchestration of several biological events in order to create any s...
© 2018 Dr. Anna Sofia Trigos GomezAll biological systems follow the rules and constraints imposed du...
The majority of cancer evolution studies involve individual-based approaches that neglect the popula...
Cancer genotyping has identified a large number of putative tumor suppressor genes. Carcinogenesis i...
<p>Over the past several decades, many genes have been discovered that govern important functions in...
This review paper is intended to bring together common features of two important new approaches to c...
Significant alterations in signaling pathways and transcriptional regulatory programs together repre...
Fate and identity of eukaryotic cells are results of the cooperative function of biological features...
Background The human genome contains a large amount of cis-regulatory DNA elements r...
AbstractAs the process of tumor progression proceeds from the normal cellular state to a preneoplast...
Carcinogenesis is commonly referred to as a multi-step process in which normal cells develop progres...
Evidence is starting to emerge indicating that tumorigenesis in metazoans involves a soma-to-germlin...