Mapping of quantitative trait loci (QTL) for muscularity in beef cattle

Muscularity is a potential indicator for the selection of more productive cattle. Mapping quantitative trait loci (QTL) for traits related to muscularity is useful to identify the genomic regions where the genes affecting muscularity reside. QTL analysis from a Limousin-Jersey double backcross herd was conducted using QTL Express software with cohort and breed as the fixed effects. Nine QTL suggested to have an association with muscularity were identified on cattle chromosomes BTA 1, 2, 3, 4, 5, 8, 12, 14 and 17. The myostatin gene is located at the centromeric end of chromosome 2 and not surprisingly, the Limousin myostatin F94L variant accounted for the QTL on BTA2. However, when the myostatin F94L genotype was included as an additional fixed effect, the QTL on BTA17 was also no longer significant. This suggests that there may be gene(s) that have epistatic effects with myostatin located on cattle chromosome 17.I. Novianti, W.S. Pitchford and C.D.K. Bottem