Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model
- Lau, D.
- Mackenzie, L.
- Kelly, D.
- Psaltis, P.
- Worthington, M.
- Rajendram, A.
- Kelly, D.
- Nelson, A.
- Zhang, Y.
- Kuklik, P.
- Brooks, A.
- Worthley, S.
- Faull, R.
- Rao, M.
- Edwards, J.
- Saint, D.
- Sanders, P.
DOIAbstract
Background: Hypertension is frequently complicated by the development of atrial fibrillation (AF). However, the mechanisms of this link remain poorly understood. In addition, whether short-term hypertension can result in a substrate for AF is not known. Objective: The purpose of this study was to characterize the atrial substrate predisposing to AF due to short-duration hypertension. Methods: Sixteen sheep were studied: 10 had induced hypertension for 7 ± 4 weeks via the “one-kidney, one-clip” model, and six were controls. Cardiac magnetic resonance imaging was used to assess functional changes. Open-chest electrophysiological study was performed using a custom-made 128-electrode epicardial plaque applied to both right (RA) and left atria (...
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