Synthesis of macrocyclic beta-Strand memplates by ring closing metathesis
- Abell, A.
- Alexander, N.
- Aitken, S.
- Chen, H.
- Coxon, J.
- Jones, M.
- McNabb, S.
- Muscroft-Taylor, A.
Publication date
January 2009
DOI Publisher
American Chemical Society (ACS) ISSN
0022-3263 Journal
The Journal of Organic Chemistry Citation count (estimate)
32Abstract
We report the synthesis of macrocycles 1-6 via ring closing metathesis of dienes 7-12. Addition of chlorodicyclohexylborane to thermal and microwave assisted RCM of dienes 8 and 9 markedly improves the yield. The geometric isomers of macrocycles 1-3 and 5 have been assigned using X-ray crystallography and NMR.Andrew D. Abell, Nathan A. Alexander, Steven G. Aitken, Hongyuan Chen, James M. Coxon, Matthew A. Jones, Stephen B. McNabb and Andrew Muscroft-Taylo
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