The interactions between hepatitis C virus (HCV) and alcohol metabolism are not well understood. To determine the effect that alcohol metabolism has on HCV replication and the antiviral action of interferon (IFN), Huh-7 cells that harbor HCV replication and metabolize ethanol via the introduced expression of cytochrome P450 2E1 (Cyp2e1) were treated with ethanol and IFN-alpha. Treatment of these cells with ethanol (0-100 mmol/L) significantly increased HCV replication. This effect was dependent on Cyp2e1 expression and alcohol-metabolized oxidative stress (OS), because the antioxidant N-acetylcysteine blocked this effect. Furthermore, the anti-HCV action of IFN-alpha was attenuated in the presence of ethanol metabolism, most likely via atte...
Hepatitis C Virus (HCV) is one of the most important causes of chronic liver disease, affecting more...
This paper reviews the role of the catabolism of HCV and signaling proteins in HCV protection and t...
The mechanisms of alcohol-induced immunosuppression include defects in innate and adaptive immune re...
Hepatitis C virus (HCV) is a significant human pathogen that in many cases, establishes a chronic li...
Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family that is estimated to have infecte...
Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwi...
Abstract Alcohol abuse reduces response rates to IFN therapy in patients with chronic hepatitis C. T...
Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family that is estimated to have infecte...
Alcohol consumption in patients infected with HCV exacerbates liver injury, leading to rapid progres...
Hepatitis C virus infection affects 170 million people worldwide, and the majority of individuals ex...
Hepatitis C virus infection affects 170 million people worldwide, and the majority of individuals ex...
Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoh...
Infection with the hepatitis C virus (HCV) has become a leading cause of scarring of the liver (i.e....
This article presents the proceedings of a symposium presented at the meeting of the Research Societ...
Background & aimsAlcohol consumption exacerbates liver injury in chronic hepatitis C, and enhanced m...
Hepatitis C Virus (HCV) is one of the most important causes of chronic liver disease, affecting more...
This paper reviews the role of the catabolism of HCV and signaling proteins in HCV protection and t...
The mechanisms of alcohol-induced immunosuppression include defects in innate and adaptive immune re...
Hepatitis C virus (HCV) is a significant human pathogen that in many cases, establishes a chronic li...
Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family that is estimated to have infecte...
Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwi...
Abstract Alcohol abuse reduces response rates to IFN therapy in patients with chronic hepatitis C. T...
Hepatitis C virus (HCV) is an RNA virus of the Flaviviridae family that is estimated to have infecte...
Alcohol consumption in patients infected with HCV exacerbates liver injury, leading to rapid progres...
Hepatitis C virus infection affects 170 million people worldwide, and the majority of individuals ex...
Hepatitis C virus infection affects 170 million people worldwide, and the majority of individuals ex...
Alcohol is the most commonly abused substance in the United States, and alcohol abuse leads to alcoh...
Infection with the hepatitis C virus (HCV) has become a leading cause of scarring of the liver (i.e....
This article presents the proceedings of a symposium presented at the meeting of the Research Societ...
Background & aimsAlcohol consumption exacerbates liver injury in chronic hepatitis C, and enhanced m...
Hepatitis C Virus (HCV) is one of the most important causes of chronic liver disease, affecting more...
This paper reviews the role of the catabolism of HCV and signaling proteins in HCV protection and t...
The mechanisms of alcohol-induced immunosuppression include defects in innate and adaptive immune re...