Corneal thickness and intraocular pressure in a nonglaucomatous Burmese population - The meiktila eye study

Objective To determine correlates of central corneal thickness (CCT) and its relationship to intraocular pressure (IOP) in a Burmese population. Methods We performed a population-based survey of inhabitants 40 years or older in Myanmar; of 2076 participants, data from 1909 nonglaucomatous subjects who underwent ultrasound pachymetry and Goldmann applanation tonometry were analyzed. Linear mixed effects models adjusting for nonindependence of right and left eye data were constructed. Results Mean (SD) CCT was 521.9 (33.3) µm, and the mean (SD) IOP was 14.5 (3.4) mm Hg. Intraocular pressure and spherical equivalent were significant predictors of CCT (P < .001 and P = .01, respectively). Age, sex, body mass index, and corneal curvature were not significant predictors. Central corneal thickness was the only significant predictor of IOP (ie, an increase of 100 µm in CCT predicted an increase of 1.3 mm Hg in IOP). The Spearman correlation between CCT and IOP for the right and left eyes was highly significant (P < .001), but the Spearman rank correlation values (R2 = 0.016 and R2 = 0.017, respectively) were weak. Conclusions The CCT in this Burmese population was significantly associated with IOP and spherical equivalent. The weak association between CCT and IOP is consistent with that of other population-based studies. Other corneal factors are likely to influence Goldmann applanation tonometry.Robert J. Casson, Lekha M. Abraham, Henry S. Newland ,James Muecke, Thomas Sullivan, Dinesh Selva, Than Aun