Dubble or nothing? Is HAUSP deubiquitylating enzyme the final arbiter of p53 levels?

Copyright © 2002 American Association for the Advancement of Science. All Rights Reserved.Signal transduction processes can be regulated by biochemical modifications that affect protein activity or localization and by protein stability. Proteins implicated in cancer, such as ß-catenin and p53, are regulated by a combination of posttranslational modifications and protein degradation by the ubiquitin-proteasome pathway. Wood explores how ubiquitylation of these proteins may not be as unidirectional as previously thought. With the identification of substrate-specific deubiquitylating enzymes, ubiquitylation may not always lead to protein destruction, but may provide another finely tunable step for controlling protein activity.Stephen A. Woo