Malaria is a parasitic disease affecting more than 200 million people in the world. The development of new antimalarial drugs is necessary in order to replace the existing treatments that are progressively becoming less efficient due to resistance phenomena. Natural products are an inexhaustible source of inspiration for the discovery of new drugs. In this project, we focused our attention on two natural products families exhibiting antimalarial properties: mallotojaponins and bromophycolides. In the first part of this project, we carried out the first total synthesis of mallotoajaponin C. We also synthesised a library of its analogues. All of these compounds were tested against Plasmodium falciparum responsible for malaria and against Tryp...
AbstractMalaria remains one of the most deadly diseases threatening humankind and is still affecting...
The work contained in this thesis is split into two sections. Each section covers a different biolog...
The war between humans and microbes is as old as our existence. Humans have created antibiotics sinc...
Malaria is a parasitic disease affecting more than 200 million people in the world. The development ...
Le paludisme est une maladie parasitaire qui présente une problématique de santé majeure, touchant a...
Tropical diseases caused by protozoan parasites such as Trypanosoma brucei, Plasmodium falciparum an...
Malaria is the more deadly parasitic disease, affecting 3.3 billion people (half of the world popula...
Les maladies tropicales provoquées par des parasites protozoaires tels que Trypanosoma brucei, Plasm...
Malaria is a tropical parasitic disease that particularly affects young children in sub-Saharan Afri...
The World Health Organization (WHO) recognizes 17 major parasitic diseases as the neglected topical ...
Le paludisme est une maladie parasitaire tropicale touchant particulièrement les jeunes enfants en A...
Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculda...
Human African Trypanosomiasis (HAT), commonly known as Sleeping Sickness, is endemic in over 36 coun...
This research explored the optimisation of three novel antimalarial series based on the MMV compound...
PhD (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria is endemic ...
AbstractMalaria remains one of the most deadly diseases threatening humankind and is still affecting...
The work contained in this thesis is split into two sections. Each section covers a different biolog...
The war between humans and microbes is as old as our existence. Humans have created antibiotics sinc...
Malaria is a parasitic disease affecting more than 200 million people in the world. The development ...
Le paludisme est une maladie parasitaire qui présente une problématique de santé majeure, touchant a...
Tropical diseases caused by protozoan parasites such as Trypanosoma brucei, Plasmodium falciparum an...
Malaria is the more deadly parasitic disease, affecting 3.3 billion people (half of the world popula...
Les maladies tropicales provoquées par des parasites protozoaires tels que Trypanosoma brucei, Plasm...
Malaria is a tropical parasitic disease that particularly affects young children in sub-Saharan Afri...
The World Health Organization (WHO) recognizes 17 major parasitic diseases as the neglected topical ...
Le paludisme est une maladie parasitaire tropicale touchant particulièrement les jeunes enfants en A...
Tese de doutoramento, Farmácia (Química Farmacêutica e Terapêutica), Universidade de Lisboa, Faculda...
Human African Trypanosomiasis (HAT), commonly known as Sleeping Sickness, is endemic in over 36 coun...
This research explored the optimisation of three novel antimalarial series based on the MMV compound...
PhD (Pharmaceutical Chemistry), North-West University, Potchefstroom Campus, 2014Malaria is endemic ...
AbstractMalaria remains one of the most deadly diseases threatening humankind and is still affecting...
The work contained in this thesis is split into two sections. Each section covers a different biolog...
The war between humans and microbes is as old as our existence. Humans have created antibiotics sinc...