Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction

Background: Growth factor-binding proteins influence the growth of infants starting in utero. Adaptation of the fetus to an adverse uterine environment is associated with changes in the growth hormone-growth factor-insulin axis. Aims: To evaluate serum levels of IGF-I and IGFBP-3 in small and appropriate for gestational age newborn infants. Methods: Fifty-four newborn infants, small (SGA, n=28) or appropriate (AGA, n=26) for gestational age were matched by gestational age and sex. Blood was collected on the first day of life, and anthropometric measurements were taken at birth. The serum levels of IGF-I and IGFBP-3 were compared, and correlated with the anthropometric measurements. Results: On the first day of life, mean serum IGFBP-3 levels were significantly lower in SGA babies and correlated with weight, length, head circumference, and ponderal index (weight/length 3) (P<0.0001). In contrast, no associations were found between IGF-I serum levels and these anthropometric measurements. Conclusion: Our data show that SGA babies have significantly reduced IGFBP-3 concentrations at birth.Peer Reviewe