Enantiomerically selective cyclopropanation

Publication Number: WO/2002/079136 International Application No.: PCT/AU2002/000417 Publication Date: 10.10.2002 International Filing Date: 02.04.2002A method of forming a cyclopropane having enhanced chirality said method comprising reacting together (1), a symmetrical 1,2-dioxine of the formula (1), wherein X and Y are the same and are groups in which a carbon atom is bonded to the dioxine backbone; and a phosphorus ylide or a phosphorus ylide precursor; in the presence of a cobalt catalyst containing a chiral ligand