Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate
- Vincent, Beverly R.
- Clarke, David John
- Smyth, Douglas Robert
- de Vos, Dick
- Tiekink, Edward Richard Tom
Publication date
January 2001
DOI Publisher
Hindawi Limited ISSN
0793-0291 Journal
Metal-Based DrugsAbstract
The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 – 2500 ng/ml).Beverly R. Vincent, David J. Clarke, Douglas R. Smyth, Dick de Vos, and Edward R. T. Tiekin
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