Analysis of a nuclear role for 'pebble', a gene required for cytokinesis in Drosophila / by Alyssa Harley.

"May 2002"Bibliography: leaves 157-176.x,176 leaves : ill. (some col.), plates (some col.) ; 30 cm.Through the use of a variety of biochemical and genetic techniques, the importance of the nuclear localisation of PBL was examined, as well as the function of its RadECl and BRCT domains. The RadECl/BRCT domains were found to be required in the cytoplasm for cytokinesis, extending the range of function attributed to these domains. PBL was also shown to shuttle between the nucleus and the cytoplasm, providing an explanation for the observed ability of nuclear PBL to influence cytoplasmic structure.Thesis (Ph.D.)--University of Adelaide, Dept. of Molecular Biosciences, 200