Structure-function studies of insulin-like growth factor I / by Gary Keith Shooter.

"20th of July 2001"Bibliography: leaves 124-165.xiv, 165 leaves : ill. (some col.), plates (col.) ; 30 cm.A study which aims at better understanding of the molecular mechanism involved in receptor binding, which may clarify the interdependence of IGF-I and insulin actions. The results suggest that factors other than receptor binding affinity may be important for determining the magnitude of the IGF-I mitogenic response. Insulin analogue studies demonstrate that the mitogenic response of the insulin receptor is related to the residence time of the ligand-receptor interaction rather than the receptor binding affinity. This study suggests that, like the insulin receptor, residence time rather than the equilibrium binding afinity may be an important factor in determining the magnitude of the mitogenic response from the type 1 IGF receptor.Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 200